ABSTRACT
Being a university student is known to be a stressful experience, and researchers across studies have reported elevated stress and compromised mental health for university students when compared with findings from the general population. The unexpected disruption to their studies arising from COVID-19 and its corresponding social isolation added to the stress experienced by students. This study assessed the effects of a virtual canine-assisted intervention to support student stress reduction and wellbeing. Participants (n = 467) were recruited from undergraduate psychology classes at a mid-size Western Canadian university and were randomly assigned to either synchronous (i.e., live Zoom) or asynchronous (i.e., pre-recorded YouTube videos) sessions with or without a dog present. An abbreviated, small group dose intervention of five minutes was used and handlers across conditions followed a script that mirrored as closely as possible the dialogue shared during a typical live, in-person visit (i.e., shared information about their dog, asked participants to reflect on their wellbeing, etc.). Measures of wellbeing included 1-item measures of connectedness to campus, loneliness, and stress, the PANAS, State-Trait Anxiety Inventory, Circumplex Model of Affect, and self-ratings of engagement during the intervention. Results of paired samples t-tests revealed that participants, regardless of condition, reported significant reductions in anxiety, stress, loneliness, and negative affect and more positive emotional states and stronger feelings of connectedness to their campus. Regarding the impact of platform delivery, participants reported greater campus connectedness following their participation in the synchronous conditions;however, type of platform was not associated with other aspects of wellbeing as noted above. As hypothesized, undergraduate students in this study did report feeling less stressed at the end of the intervention when a dog was present. The implications of the findings are discussed within the context of university student wellbeing. (PsycInfo Database Record (c) 2022 APA, all rights reserved)
ABSTRACT
Immune system dysfunction is paramount in coronavirus disease 2019 (COVID-19) severity and fatality rate. Mucosal-associated invariant T (MAIT) cells are innate-like T cells involved in mucosal immunity and protection against viral infections. Here, we studied the immune cell landscape, with emphasis on MAIT cells, in cohorts totaling 208 patients with various stages of disease. MAIT cell frequency is strongly reduced in blood. They display a strong activated and cytotoxic phenotype that is more pronounced in lungs. Blood MAIT cell alterations positively correlate with the activation of other innate cells, proinflammatory cytokines, notably interleukin (IL)-18, and with the severity and mortality of severe acute respiratory syndrome coronavirus 2 infection. We also identified a monocyte/macrophage interferon (IFN)-α-IL-18 cytokine shift and the ability of infected macrophages to induce the cytotoxicity of MAIT cells in an MR1-dependent manner. Together, our results suggest that altered MAIT cell functions due to IFN-α-IL-18 imbalance contribute to disease severity, and their therapeutic manipulation may prevent deleterious inflammation in COVID-19 aggravation.